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'Keep a close watch on situation': Government to officials amid Monkeypox cases in Europe


Monkeypox_AP

NEW DELHI: Amid cases of Monkeypox reported in a few countries, Union Health Minister Mansukh Mandaviya has directed the National Centre for Disease Control and the ICMR to keep a close watch on the situation, official sources said Friday.

The Union health ministry has also directed airport and port health officers to be vigilant, they said.

"They have been instructed that any sick passenger with a travel history to Monkeypox-affected countries be isolated and samples sent to the BSL4 facility of the National Institute of Virology in Pune for an investigation," an official source said.

He added, "The Union Health Minister on Thursday directed the National Centre for Disease Control and the ICMR to keep a close watch and monitor the situation in India."

Cases of Monkeypox have been reported from the UK, the USA, Portugal, Spain, and some other European countries.

In humans, the symptoms of Monkeypox are similar to but milder than those of smallpox.

According to the WHO, Monkeypox typically manifests in humans with a fever, rashes and swollen lymph nodes and may lead to a range of medical complications.

Monkeypox is usually a self-limited disease with the symptoms lasting from two to four weeks.

It can also take a severe from, with the WHO saying the case fatality ratio has been around 3-6 per cent in recent times.

Monkeypox virus is transmitted from one person to another by close contact with lesions, body fluids, respiratory droplets and contaminated materials such as bedding.

The clinical presentation of monkeypox resembles that of smallpox, the WHO says.

Transmission of the disease can also occur via the placenta from mother to fetus (which can lead to congenital Monkeypox) or close contact during and after birth, the world health body says.

While close physical contact is a well-known risk factor for transmission, it is unclear at this time if monkeypox can be transmitted specifically through sexual transmission routes, according to the WHO.

As more cases of monkeypox are detected in Europe and North America, some scientists who have monitored numerous outbreaks in Africa say they are baffled by the unusual disease's spread in developed countries.

Cases of the smallpox-related disease haven't previously been seen among people with no links to central and West Africa.

But in the past week, Britain, Spain, Portugal, Italy, US, Sweden and Canada all reported infections, mostly in young men who hadn't previously travelled to Africa.

France, Germany, Belgium and Australia confirmed their first cases of monkeypox on Friday.

"I'm stunned by this. Every day I wake up and there are more countries infected," said Oyewale Tomori, a virologist who formerly headed the Nigerian Academy of Science and who sits on several World Health Organization advisory boards.

"This is not the kind of spread we've seen in West Africa, so there may be something new happening in the West," he said.

Monkeypox typically causes fever, chills, a rash and lesions on the face or genitals.

WHO estimates the disease is fatal for about one in 10 people, but smallpox vaccines are protective and some antiviral drugs are also being developed.

One of the theories British health officials are exploring is whether the disease is being sexually transmitted.

Health officials have asked doctors and nurses to be on alert for potential cases, but said the risk to the general population is low.

Outbreaks in Nigeria, which reports about 3,000 monkeypox cases a year, are usually in rural areas, where people have close contact with infected rats and squirrels, according to Tomori.

He said the disease is not spread very easily and that many cases are likely missed.

"Unless the person ends up in an advanced health centre, they don't attract the attention of the surveillance system," he said.

Tomori hoped the appearance of monkeypox cases across Europe and other countries would further scientific understanding of the disease.

The World Health Organisation's lead on emergency response, Dr. Ibrahima Soce Fall, acknowledged this week that there were still "so many unknowns in terms of the dynamics of transmission, the clinical features (and) the epidemiology."

On Friday, Britain's Health Security Agency reported 11 new monkeypox cases, saying that "a notable proportion" of the most recent infections in the U.K.

and Europe have been in young men with no history of travel to Africa who were gay, bisexual, or had sex with men.

Authorities in Spain and Portugal also said their cases were in young men who mostly had sex with other men and said those cases were picked up when the men turned up with lesions at sexual health clinics.

Experts have stressed they do not know if the disease is being spread through sex, or other close contact related to sex.

"This is not something we've seen in Nigeria," virologist Tomori said.

He said viruses that hadn't initially been known to transmit via sex, like Ebola, were later proven to do so after bigger epidemics showed different patterns of spread.

The same could be true of monkeypox, Tomori said.

"We would have to go back through our records to see if this might have happened, like between a husband and wife," he said.

In Germany, Health Minister Karl Lauterbach said the government was confident the outbreak could be contained.

He said the virus was being sequenced to see if there were any genetic changes that might have made it more infectious.

Rolf Gustafson, an infectious diseases professor, told Swedish broadcaster SVT that it was "very difficult" to imagine the situation might worsen.

"We will certainly find some further cases in Sweden, but I do not think there will be an epidemic in any way. There is nothing to suggest that at present."

Scientists said that while it's possible the outbreak's first patient caught the disease while in Africa, what's happening now is exceptional.

"We've never seen anything like what's happening in Europe," Christian Happi, director of the African Centre of Excellence for Genomics of Infectious Diseases, said.

"We haven't seen anything to say that the transmission patterns of monkeypox have been changing in Africa, so if something different is happening in Europe, then Europe needs to investigate that."

Happi also pointed out that the suspension of smallpox vaccination campaigns after the disease was eradicated in 1980 might inadvertently be helping monkeypox spread.

Smallpox vaccines also protect against monkeypox, but mass immunisation was stopped decades ago.

"Aside from people in west and Central Africa who may have some immunity to monkeypox from past exposure, not having any smallpox vaccination means nobody has any kind of immunity to monkeypox," Happi said.

Shabir Mahdi, a professor of vaccinology at the University of Witwatersrand in Johannesburg, said a detailed investigation of the outbreak in Europe, including determining who the first patients were, was now critical.

"We need to really understand how this first started and why the virus is now gaining traction," he said.

"In Africa, there have been very controlled and infrequent outbreaks of monkeypox. If that's now changing, we really need to understand why."

(With AP Inputs)

(THE NEW INDIAN EXPRESS)